Firstly, in addition to the common European rules, the whole territory of the Czech Republic is located in the LKR10-UAS restricted airspace. That basically means that the older stricter national rules remain in power in addition to the default lax European rules.
Secondly, most of Prague is a densely built area. The UA operation is forbidden with the exception of UAs in the SPECIFIC or CERTIFIED category that are licensed by the CAA (ÚCL). The OPEN category is not allowed. Toys that do not require registration are allowed.
Additionally, the territory of Prague is located in CTR Ruzyně where the rules for UAs in the controlled airport area must be observed. Thankfully, the operation of drones is possible up to 100 m AGL if farther than 5500 m from the airport.
Also, most interesting part of Prague is located in the LKR9 restricted airspace. You cannot operate a UA without an operation approval from the CAA (ÚCL). Do note that you will need the approval for each operation, you will not get a blanket approval to fly there for a week, at best for some specific repeated flights that follow some common pattern regularly.
So realistically, you need to get your drone running in the SPECIFIC or CERTIFIED category in the Czech Republic and to get yourself certified to operate UAs in one of these categories. You wrote you have "a license" but from a certain naivety of the question I have to assume it is actually just a registration of a pilot and drone in the OPEN category, but do correct me if I am wrong.
Be prepared for a lot of paperwork. It is basically meant for professionals conducting for-profit aerial work in the area.
Then you can get approval to operate them also in the LKR9 airspace.